NCT04113447 · Observational
Mitochondrial Donation: An 18 Month Outcome Study.
Mitochondrial Diseases
Study overall: Recruiting · source record updated 20 July 2025.
1 England locations · 1 explicitly recorded as recruiting.
RESEARCH IN ENGLAND
Explore clinical trials with England locations
Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.
208 matching studies · ordered by study identifier.
The area filter uses exact source postcodes. Locations without a matched postcode remain in the England-wide results.
NCT04116502 · Interventional
MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera
Polycythemia Vera
Study overall: Recruiting · source record updated 28 April 2026.
40 England locations · 38 explicitly recorded as recruiting.
NCT04204915 · Interventional
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
Aortic Stenosis
Study overall: Recruiting · source record updated 21 July 2026.
66 England locations · 63 explicitly recorded as recruiting.
NCT04253015 · Observational
A Post-Authorisation Safety Study Patient Registry of Patients With Neuroblastoma Being Treated With Dinutuximab Beta
Neuroblastoma
Study overall: Recruiting · source record updated 7 February 2024.
3 England locations · 2 explicitly recorded as recruiting.
NCT04274283 · Observational
Tessa Jowell BRAIN MATRIX - Platform Study
Glioma
Study overall: Recruiting · source record updated 5 May 2026.
11 England locations · 10 explicitly recorded as recruiting.
NCT04292574 · Observational
UK SMA Patient Registry
Spinal Muscular Atrophy · SMA
Study overall: Recruiting · source record updated 20 August 2026.
1 England locations · 1 explicitly recorded as recruiting.
NCT04302870 · Interventional
Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Study overall: Recruiting · source record updated 4 March 2026.
15 England locations · 15 explicitly recorded as recruiting.
NCT04307576 · Interventional
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
Leukemia, Acute Lymphoblastic
Study overall: Recruiting · source record updated 12 August 2026.
27 England locations · 23 explicitly recorded as recruiting.
NCT04442334 · Observational
The European NAFLD Registry
NAFLD · NASH · NASH - Nonalcoholic Steatohepatitis · Fibrosis, Liver · Steatosis of Liver · Hepatocellular Carcinoma · Cardiovascular Diseases · Type 2 Diabetes · Dyslipidaemia · Hypertension · Obesity · Other Associated Comorbidities
Study overall: Recruiting · source record updated 6 January 2023.
11 England locations · 10 explicitly recorded as recruiting.
NCT04477785 · Observational
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
Parkinson Disease
Study overall: Recruiting · source record updated 27 July 2026.
4 England locations · 4 explicitly recorded as recruiting.
NCT04663750 · Interventional
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
Eye Diseases · Macular Degeneration, Wet · Sub-Macular Hemorrhage
Study overall: Recruiting · source record updated 15 May 2026.
23 England locations · 22 explicitly recorded as recruiting.
NCT04685616 · Interventional
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Hodgkin Lymphoma
Study overall: Recruiting · source record updated 8 July 2026.
26 England locations · 26 explicitly recorded as recruiting.
NCT04723316 · Observational
Tumour Characterisation to Guide Experimental Targeted Therapy - National
Cancer
Study overall: Recruiting · source record updated 7 February 2024.
16 England locations · 15 explicitly recorded as recruiting.
NCT04775485 · Interventional
A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors
Low-grade Glioma · Advanced Solid Tumor
Study overall: Recruiting · source record updated 10 April 2025.
2 England locations · 2 explicitly recorded as recruiting.
NCT04817618 · Interventional
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
C3G
Study overall: Recruiting · source record updated 13 July 2026.
3 England locations · 0 explicitly recorded as recruiting.
NCT04888741 · Interventional
Methods of T Cell Depletion Trial (MoTD)
Acute Myeloid Leukemia · Acute Lymphoblastic Leukemia · Chronic Myelomonocytic Leukemia · Myelodysplastic Syndromes · Non Hodgkin Lymphoma · Hodgkin Lymphoma · Multiple Myeloma · Chronic Myelogenous Leukemia · Myelofibrosis
Study overall: Recruiting · source record updated 5 May 2026.
15 England locations · 15 explicitly recorded as recruiting.
NCT04892173 · Interventional
JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC
Carcinoma, Squamous Cell
Study overall: Recruiting · source record updated 28 August 2026.
4 England locations · 4 explicitly recorded as recruiting.
NCT04939935 · Interventional
Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)
Autosomal Dominant Polycystic Kidney Disease
Study overall: Recruiting · source record updated 31 March 2026.
25 England locations · 15 explicitly recorded as recruiting.
NCT04965298 · Interventional
Treating People With Idiopathic Pulmonary Fibrosis With the Addition of Lansoprazole
Idiopathic Pulmonary Fibrosis
Study overall: Recruiting · source record updated 22 December 2025.
50 England locations · 36 explicitly recorded as recruiting.
NCT04969835 · Interventional
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
Salivary Gland Tumor · Urothelial Carcinoma · Ovarian Carcinoma · Breast Cancer · Soft Tissue Sarcoma
Study overall: Recruiting · source record updated 15 May 2026.
5 England locations · 4 explicitly recorded as recruiting.
More ways to explore research
This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.