NCT04204915 · Interventional
The Early Valve Replacement in Severe ASYmptomatic Aortic Stenosis Study
Aortic Stenosis
Study overall: Recruiting · source record updated 21 July 2026.
66 England locations · 63 explicitly recorded as recruiting.
RESEARCH IN ENGLAND
Explore clinical trials with England locations
Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.
196 matching studies · ordered by study identifier.
The area filter uses exact source postcodes. Locations without a matched postcode remain in the England-wide results.
NCT04274283 · Observational
Tessa Jowell BRAIN MATRIX - Platform Study
Glioma
Study overall: Recruiting · source record updated 5 May 2026.
11 England locations · 10 explicitly recorded as recruiting.
NCT04307576 · Interventional
A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia
Leukemia, Acute Lymphoblastic
Study overall: Recruiting · source record updated 12 August 2026.
27 England locations · 23 explicitly recorded as recruiting.
NCT04685616 · Interventional
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Hodgkin Lymphoma
Study overall: Recruiting · source record updated 8 July 2026.
26 England locations · 26 explicitly recorded as recruiting.
NCT04723316 · Observational
Tumour Characterisation to Guide Experimental Targeted Therapy - National
Cancer
Study overall: Recruiting · source record updated 7 February 2024.
16 England locations · 15 explicitly recorded as recruiting.
NCT04811560 · Interventional
A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)
Acute Leukemia
Study overall: Recruiting · source record updated 28 August 2026.
7 England locations · 7 explicitly recorded as recruiting.
NCT04888741 · Interventional
Methods of T Cell Depletion Trial (MoTD)
Acute Myeloid Leukemia · Acute Lymphoblastic Leukemia · Chronic Myelomonocytic Leukemia · Myelodysplastic Syndromes · Non Hodgkin Lymphoma · Hodgkin Lymphoma · Multiple Myeloma · Chronic Myelogenous Leukemia · Myelofibrosis
Study overall: Recruiting · source record updated 5 May 2026.
15 England locations · 15 explicitly recorded as recruiting.
NCT04895436 · Interventional
Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)
Chronic Lymphocytic Leukemia (CLL)
Study overall: Recruiting · source record updated 9 February 2026.
3 England locations · 3 explicitly recorded as recruiting.
NCT04965298 · Interventional
Treating People With Idiopathic Pulmonary Fibrosis With the Addition of Lansoprazole
Idiopathic Pulmonary Fibrosis
Study overall: Recruiting · source record updated 22 December 2025.
50 England locations · 36 explicitly recorded as recruiting.
NCT04969835 · Interventional
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
Salivary Gland Tumor · Urothelial Carcinoma · Ovarian Carcinoma · Breast Cancer · Soft Tissue Sarcoma
Study overall: Recruiting · source record updated 15 May 2026.
5 England locations · 4 explicitly recorded as recruiting.
NCT04996875 · Interventional
(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis
Advanced Systemic Mastocytosis (AdvSM) · SM With an Associated Hematologic Neoplasm (SM-AHN) · Mast Cell Leukemia (MCL) · Aggressive Systemic Mastocytosis (ASM)
Study overall: Recruiting · source record updated 31 July 2026.
3 England locations · 3 explicitly recorded as recruiting.
NCT05006716 · Interventional
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
B-cell Malignancy · Marginal Zone Lymphoma · Follicular Lymphoma · Non-Hodgkin Lymphoma · Waldenström Macroglobulinemia · Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma · Mantle Cell Lymphoma · Diffuse Large B Cell Lymphoma
Study overall: Recruiting · source record updated 21 August 2026.
6 England locations · 6 explicitly recorded as recruiting.
NCT05022485 · Observational
Zimmer® Natural Nail® (ZNN) Bactiguard Tibia Post-Market Clinical Follow-up Study
Tibial Fractures · Fracture Infection
Study overall: Recruiting · source record updated 25 November 2025.
3 England locations · 3 explicitly recorded as recruiting.
NCT05120596 · Interventional
First in Human Study of T3P-Y058-739 (T3P)
Advanced Solid Tumor
Study overall: Recruiting · source record updated 13 April 2026.
3 England locations · 3 explicitly recorded as recruiting.
NCT05131022 · Interventional
A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies
Chronic Lymphocytic Leukemia (CLL) · Small Lymphocytic Lymphoma (SLL) · Diffuse Large B Cell Lymphoma (DLBCL) · Follicular Lymphoma (FL) · Mantle Cell Lymphoma (MCL) · Marginal Zone Lymphoma (MZL) · Waldenstrom Macroglobulinemia (WM) · Primary Central Nervous System Lymphoma (PCNSL) · Secondary Central Nervous System Lymphoma (SCNSL)
Study overall: Recruiting · source record updated 2 July 2026.
9 England locations · 9 explicitly recorded as recruiting.
NCT05197322 · Interventional
NEOadjuvant PembRolizumab In Stratified Medicine - ColoRectal Cancer
Adenocarcinoma of the Colon
Study overall: Recruiting · source record updated 17 April 2026.
5 England locations · 3 explicitly recorded as recruiting.
NCT05253651 · Interventional
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Colorectal Neoplasms
Study overall: Recruiting · source record updated 22 July 2026.
10 England locations · 10 explicitly recorded as recruiting.
NCT05276674 · Observational
ZNN Bactiguard Retrograde Femoral Nails PMCF Study
Femoral Fracture
Study overall: Recruiting · source record updated 3 February 2026.
3 England locations · 2 explicitly recorded as recruiting.
NCT05318534 · Interventional
Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease
First in Man Study to Evaluate Initial Safety
Study overall: Recruiting · source record updated 6 March 2026.
1 England locations · 1 explicitly recorded as recruiting.
NCT05441839 · Observational
UK Heart Failure With Preserved Ejection Fraction
Heart Failure With Preserved Ejection Fraction (HFpEF)
Study overall: Recruiting · source record updated 6 May 2025.
22 England locations · 22 explicitly recorded as recruiting.
More ways to explore research
This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.