RESEARCH IN ENGLAND

Explore clinical trials with England locations

Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.

Condition, study or locationRecorded care areaStatus at an England locationClear filters

266 matching studies · ordered by study identifier.

The area filter uses exact source postcodes. Locations without a matched postcode remain in the England-wide results.

NCT05549258 · Interventional

Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

Neuromyelitis Optica Spectrum Disorder

Study overall: Recruiting · source record updated 5 December 2025.

3 England locations · 3 explicitly recorded as recruiting.

NCT05549297 · Interventional

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

Advanced Melanoma

Study overall: Recruiting · source record updated 25 February 2026.

9 England locations · 9 explicitly recorded as recruiting.

NCT05552222 · Interventional

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

Multiple Myeloma

Study overall: Recruiting · source record updated 28 August 2026.

8 England locations · 8 explicitly recorded as recruiting.

NCT05611801 · Interventional

A Clinical Trial of Study Medicine (Marstacimab) in Pediatric Patients With Hemophilia A or Hemophilia B

Hemophilia A · Hemophilia B

Study overall: Recruiting · source record updated 10 August 2026.

5 England locations · 5 explicitly recorded as recruiting.

NCT05629702 · Interventional

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

Glioblastoma · Brain Tumor · Cannabis · Brain Tumor, Recurrent

Study overall: Recruiting · source record updated 5 May 2026.

16 England locations · 14 explicitly recorded as recruiting.

NCT05633654 · Interventional

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

Triple Negative Breast Cancer

Study overall: Recruiting · source record updated 9 September 2026.

10 England locations · 4 explicitly recorded as recruiting.

NCT05669950 · Interventional

A Trial of Lu AG13909 in Participants With Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia

Study overall: Recruiting · source record updated 9 March 2026.

4 England locations · 4 explicitly recorded as recruiting.

NCT05722886 · Interventional

DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol

Haematological Malignancy · Solid Tumour

Study overall: Recruiting · source record updated 1 July 2026.

21 England locations · 20 explicitly recorded as recruiting.

NCT05727904 · Interventional

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

Metastatic Melanoma · Unresectable Melanoma · Melanoma

Study overall: Recruiting · source record updated 26 June 2026.

5 England locations · 5 explicitly recorded as recruiting.

NCT05730036 · Interventional

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

Relapsed Refractory Multiple Myeloma (RRMM)

Study overall: Recruiting · source record updated 6 March 2026.

7 England locations · 0 explicitly recorded as recruiting.

NCT05768178 · Interventional

DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

Haematological Malignancy · Melanoma · Thyroid Cancer, Papillary · Ovarian Neoplasms · Colorectal Neoplasms · Laryngeal Neoplasms · Carcinoma, Non-Small-Cell Lung · Glioma · Multiple Myeloma · Erdheim-Chester Disease · Thyroid Carcinoma, Anaplastic · Solid Tumour

Study overall: Recruiting · source record updated 24 November 2025.

12 England locations · 12 explicitly recorded as recruiting.

NCT05770037 · Interventional

DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers

Haematological Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Anaplastic Large Cell Lymphoma · Lymphoma · Renal Cell Carcinoma · Neuroblastoma · Solid Tumour

Study overall: Recruiting · source record updated 24 November 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05770102 · Interventional

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition

Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Colorectal Neoplasms · Endometrial Neoplasms · Melanoma · Solid Tumours

Study overall: Recruiting · source record updated 24 November 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05770544 · Interventional

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.

Haematological Malignancy · Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Brain Neoplasms · Melanoma · Glioma · Solid Tumour

Study overall: Recruiting · source record updated 24 November 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05776069 · Interventional

Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)

Von Willebrand Diseases

Study overall: Recruiting · source record updated 26 August 2025.

5 England locations · 5 explicitly recorded as recruiting.

NCT05786716 · Interventional

DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations

Haematological Malignancy · Colorectal Neoplasms · Urinary Bladder Neoplasm · Gallbladder Neoplasms · Salivary Gland Neoplasm · Lung Neoplasm · Pancreatic Neoplasm · Ovarian Neoplasms · Prostatic Neoplasm · Skin Neoplasm · Solid Tumour

Study overall: Recruiting · source record updated 2 December 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05789758 · Observational

A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Before or During Pregnancy And About The Health of Their Babies

Muscular Atrophy, Spinal

Study overall: Recruiting · source record updated 9 March 2026.

10 England locations · 10 explicitly recorded as recruiting.

NCT05808543 · Interventional

BEARS Training Package to Maximise Hearing Abilities in Older Children and Teenagers With Bilateral Cochlear Implants

Hearing Loss, Sensorineural · Hearing Loss · Deafness · Hearing Impaired Children and Adolescents

Study overall: Recruiting · source record updated 1 April 2026.

12 England locations · 11 explicitly recorded as recruiting.

NCT05835310 · Interventional

An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

Systemic Lupus Erythematosus

Study overall: Recruiting · source record updated 10 September 2026.

7 England locations · 7 explicitly recorded as recruiting.

NCT05855200 · Interventional

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

Colonic Neoplasms · Neoplasms, Colon

Study overall: Recruiting · source record updated 23 January 2026.

9 England locations · 9 explicitly recorded as recruiting.

More ways to explore research

This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.

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Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).

Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.

How we selected and connected these records

Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.