NCT05633654
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Registered research study with 10 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Triple Negative Breast Cancer
- Lead sponsor
- Gilead Sciences
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase3
- Study record last updated
- 9 September 2026
- Study team last verified status
- 2026-09
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Hull University Teaching Hospitals NHS Trust Cottingham · HU165JQ | Not yet recruiting | Care in East Riding of Yorkshire England postcode |
| University Hospitals Birmingham NHS Foundation Trust Edgbaston · B152TH | Not yet recruiting | Care in Birmingham England postcode |
| The Clatterbridge Cancer Centre NHS Foundation Trust Liverpool · L7 8YA | Not yet recruiting | Care in Liverpool England postcode |
| Barts Health NHS Trust London · EC1M 6QB | Recruiting | England location Source location point within ONS England boundary |
| Guy's Hospital London · SE1 9RT | Not yet recruiting | Care in Southwark England postcode |
| Royal Marsden Hospital London · SW10 9NH | Recruiting | Care in Kensington and Chelsea England postcode |
| The Christie NHS Foundation Trust Manchester · M20 4BX | Recruiting | Care in Manchester England postcode |
| East and North Hertfordshire NHS Trust Northwood · HA6 2RN | Not yet recruiting | Care in Hillingdon England postcode |
| Taunton and Somerset NHS Foundation Trust Taunton · TA1 5DA | Recruiting | Care in Somerset England postcode |
| York Teaching Hospital NHS Foundation Trust York · YO31 8HE | Not yet recruiting | Care in York England postcode |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.