NCT05768178 · DETERMINE
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
Registered research study with 12 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Haematological Malignancy; Melanoma; Thyroid Cancer, Papillary; Ovarian Neoplasms; Colorectal Neoplasms; Laryngeal Neoplasms; Carcinoma, Non-Small-Cell Lung; Glioma; Multiple Myeloma; Erdheim-Chester Disease; Thyroid Carcinoma, Anaplastic; Solid Tumour
- Lead sponsor
- Cancer Research UK
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase2, Phase3
- Study record last updated
- 24 November 2025
- Study team last verified status
- 2025-11
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| University Hospital Birmingham Birmingham · B15 2TT | Recruiting | Care in Birmingham England postcode |
| Bristol Haematology and Oncology Centre Bristol · BS2 8ED | Recruiting | Care in Bristol England postcode |
| Addenbrooke's Hospital Cambridge · CB2 OQQ | Recruiting | England location Source location point within ONS England boundary |
| Leicester Royal Infirmary Leicester · LE1 5WW | Recruiting | Care in Leicester England postcode |
| University College London Hospital London · NW1 2BU | Recruiting | Care in Camden England postcode |
| Guy's Hospital London · SE1 9RT | Recruiting | Care in Southwark England postcode |
| The Christie Hospital Manchester · M20 4BX | Recruiting | Care in Manchester England postcode |
| Clatterbridge Cancer Centre Metropolitan Borough of Wirral · CH63 4JY | Recruiting | Care in Wirral England postcode |
| Freeman Hospital Newcastle · NE7 7DN | Recruiting | Care in Newcastle upon Tyne England postcode |
| Churchill Hospital Oxford · OX3 7LE | Recruiting | Care in Oxford England postcode |
| Weston Park Hospital Sheffield · S10 2SJ | Recruiting | Care in Sheffield England postcode |
| Southampton General Hospital Southampton · SO16 6YD | Recruiting | Care in Southampton England postcode |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.