NCT04645251 · Observational
Polycystic Liver Disease Registry (UK)
Polycystic Liver Disease
Study overall: Recruiting · source record updated 23 December 2025.
1 England locations · 1 explicitly recorded as recruiting.
RESEARCH IN ENGLAND
Explore clinical trials with England locations
Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.
2,970 matching studies · ordered by study identifier.
NCT04649242 · Interventional
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Pediatric Migraine
Study overall: Recruiting · source record updated 14 August 2026.
3 England locations · 2 explicitly recorded as recruiting.
NCT04657068 · Interventional
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Advanced Cancer · Metastatic Cancer · Ovarian Cancer · Primary Peritoneal Cancer · Fallopian Tube Cancer · Endometrial Cancer · Metastatic Colorectal Cancer · Pancreatic Ductal Adenocarcinoma · Acinar Cell Carcinoma
Study overall: Recruiting · source record updated 30 July 2026.
3 England locations · 3 explicitly recorded as recruiting.
NCT04661059 · Observational
Study of Late-foetal Human Organ Development
Congenital Disorders
Study overall: Recruiting · source record updated 5 December 2023.
1 England locations · 1 explicitly recorded as recruiting.
NCT04663204 · Interventional
A Study of the Safety and Activity of Sparsentan for the Treatment of Patients With Immunoglobulin A Nephropathy
Immunoglobulin A Nephropathy · Kidney Diseases · Glomerulonephritis, IGA · Glomerulonephritis · Autoimmune Diseases · Immune System Diseases
Study overall: Recruiting · source record updated 3 June 2026.
4 England locations · 4 explicitly recorded as recruiting.
NCT04663750 · Interventional
Vitrectomy, Subretinal Tissue Plasminogen Activator (TPA) and Intravitreal Gas for Submacular Haemorrhage Secondary to Exudative (Wet) Age-related Macular Degeneration (TIGER).
Eye Diseases · Macular Degeneration, Wet · Sub-Macular Hemorrhage
Study overall: Recruiting · source record updated 15 May 2026.
23 England locations · 22 explicitly recorded as recruiting.
NCT04664686 · Interventional
Rate or Rhythm Control in CRT: the RHYTHMIC Study
Atrial Fibrillation · Heart Failure
Study overall: Recruiting · source record updated 26 January 2026.
1 England locations · 1 explicitly recorded as recruiting.
NCT04666402 · Observational
Integrated Diagnostics for Early Diagnosis of Liver Disease
Non-Alcoholic Fatty Liver Disease · Non-alcoholic Steatohepatitis · Alcoholic Liver Disease · Liver Fibroses
Study overall: Recruiting · source record updated 9 February 2026.
1 England locations · 1 explicitly recorded as recruiting.
NCT04670172 · Observational
Real-Life Chronic Rhinosinusitis Outcome Registry
Chronic Rhinosinusitis (Diagnosis)
Study overall: Recruiting · source record updated 13 February 2025.
1 England locations · 1 explicitly recorded as recruiting.
NCT04671940 · Observational
Exploratory Study of Clonal Evolution in Cancer for Patients Undergoing Transoral Robotic Surgery for Radiation Exposed Residual/reCurrent Tumours of the Upper Aerodigestive Tract
Head and Neck Cancer
Study overall: Recruiting · source record updated 12 February 2026.
1 England locations · 1 explicitly recorded as recruiting.
NCT04674449 · Interventional
iCorMicA - Stratified Medicine in Angina
Microvascular Angina · Angina, Stable · Ischemia With No Obstructive Coronary Arteries (INOCA) · Coronary Microvascular Dysfunction (CMD) · Ischaemic Heart Disease · Non-Obstructive Coronary Atherosclerosis · Coronary Artery Disease · Vasospastic Angina · Coronary; Ischemic · Angina Attacks
Study overall: Recruiting · source record updated 9 April 2026.
25 England locations · 20 explicitly recorded as recruiting.
NCT04685616 · Interventional
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
Hodgkin Lymphoma
Study overall: Recruiting · source record updated 8 July 2026.
26 England locations · 26 explicitly recorded as recruiting.
NCT04688190 · Observational
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
Mitral Regurgitation · Mitral Valve Disease · Mitral Annular Calcification
Study overall: Recruiting · source record updated 7 May 2026.
2 England locations · 2 explicitly recorded as recruiting.
NCT04698291 · Observational
Genetic Variants and Regulation of Specialized Pro-resolving Mediator
Healthy · Inflammatory Disease · Cardiovascular Diseases
Study overall: Recruiting · source record updated 5 February 2026.
1 England locations · 1 explicitly recorded as recruiting.
NCT04700826 · Interventional
Preventing Stroke, Premature Death and Cognitive Decline in a Broader Community of Patients With Atrial Fibrillation
Atrial Fibrillation
Study overall: Recruiting · source record updated 16 May 2025.
1 England locations · 1 explicitly recorded as recruiting.
NCT04710576 · Interventional
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
Chronic Graft-versus-host-disease
Study overall: Recruiting · source record updated 16 June 2026.
4 England locations · 0 explicitly recorded as recruiting.
NCT04723316 · Observational
Tumour Characterisation to Guide Experimental Targeted Therapy - National
Cancer
Study overall: Recruiting · source record updated 7 February 2024.
16 England locations · 15 explicitly recorded as recruiting.
NCT04728893 · Interventional
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)
Hematologic Malignancies · Waldenstroms Macroglobulinaemia · Non-Hodgkins Lymphoma · Chronic Lymphocytic Leukaemia
Study overall: Recruiting · source record updated 21 August 2026.
8 England locations · 8 explicitly recorded as recruiting.
NCT04735835 · Interventional
Personalized Responses to Dietary Composition Trial 3
Diabetes · Heart Diseases · Diet Habit · Diet Modification · Healthy · Obesity · Metabolism · Microbial Colonization
Study overall: Recruiting · source record updated 16 April 2025.
1 England locations · 1 explicitly recorded as recruiting.
NCT04741230 · Interventional
Investigator Initiated, Prospective Study of Xenia Corneal Lenticule
Keratoconus · Post-Laser Retinal Condition
Study overall: Recruiting · source record updated 15 January 2026.
1 England locations · 1 explicitly recorded as recruiting.
More ways to explore research
This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.