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RESEARCH IN ENGLAND

Explore clinical trials with England locations

Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.

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421 matching studies · ordered by study identifier.

The area filter uses exact source postcodes. Locations without a matched postcode remain in the England-wide results.

NCT05658640 · Interventional

HEM iSMART-D: Trametinib + Dexamethasone + Chemotherapy in Children With Relapsed or Refractory Hematological Malignancies

Acute Lymphoblastic Leukemia, in Relapse · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Study overall: Recruiting · source record updated 16 September 2025.

5 England locations · 0 explicitly recorded as recruiting.

NCT05768178 · Interventional

DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

Haematological Malignancy · Melanoma · Thyroid Cancer, Papillary · Ovarian Neoplasms · Colorectal Neoplasms · Laryngeal Neoplasms · Carcinoma, Non-Small-Cell Lung · Glioma · Multiple Myeloma · Erdheim-Chester Disease · Thyroid Carcinoma, Anaplastic · Solid Tumour

Study overall: Recruiting · source record updated 24 November 2025.

12 England locations · 12 explicitly recorded as recruiting.

NCT05770037 · Interventional

DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers

Haematological Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Anaplastic Large Cell Lymphoma · Lymphoma · Renal Cell Carcinoma · Neuroblastoma · Solid Tumour

Study overall: Recruiting · source record updated 24 November 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05770102 · Interventional

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition

Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Colorectal Neoplasms · Endometrial Neoplasms · Melanoma · Solid Tumours

Study overall: Recruiting · source record updated 24 November 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05770544 · Interventional

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.

Haematological Malignancy · Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Brain Neoplasms · Melanoma · Glioma · Solid Tumour

Study overall: Recruiting · source record updated 24 November 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05786716 · Interventional

DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations

Haematological Malignancy · Colorectal Neoplasms · Urinary Bladder Neoplasm · Gallbladder Neoplasms · Salivary Gland Neoplasm · Lung Neoplasm · Pancreatic Neoplasm · Ovarian Neoplasms · Prostatic Neoplasm · Skin Neoplasm · Solid Tumour

Study overall: Recruiting · source record updated 2 December 2025.

21 England locations · 19 explicitly recorded as recruiting.

NCT05786924 · Interventional

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Non-small Cell Lung Cancer · Histiocytic Neoplasm · Histiocytosis · BRAF Gene Mutation · BRAF V600E · BRAF V600 Mutation · BRAF Mutation-Related Tumors · BRAF · Metastatic Lung Non-Small Cell Carcinoma · Metastatic Lung Cancer · Recurrent Lung Cancer · Recurrent Lung Non-Small Cell Carcinoma · NSCLC · Solid Tumor · Solid Carcinoma · KRAS G12D · KRAS G12V · KRAS Mutation-Related Tumors · NRAS Gene Mutation · Thyroid Cancer · Thyroid Carcinoma · Colorectal Cancer · Colorectal Carcinoma · Recurrent Histiocytic and Dendritic Cell Neoplasm · Brain Metastases · Recurrent NSCLC · KRAS G13C · Acquired Resistance to KRAS G12C Inhibitor · KRAS G12A · KRAS G12F · KRAS G12R · KRAS G13D

Study overall: Recruiting · source record updated 17 June 2026.

3 England locations · 3 explicitly recorded as recruiting.

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This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.

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Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).

Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.

How we selected and connected these records

Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.