NCT05720117 · Interventional
A Study of PYX-201 in Advanced Solid Tumors
Solid Tumor · Advanced Solid Tumor
Study overall: Recruiting · source record updated 30 June 2026.
3 England locations · 2 explicitly recorded as recruiting.
RESEARCH IN ENGLAND
Explore clinical trials with England locations
Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.
479 matching studies · ordered by study identifier.
The area filter uses exact source postcodes. Locations without a matched postcode remain in the England-wide results.
NCT05722886 · Interventional
DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol
Haematological Malignancy · Solid Tumour
Study overall: Recruiting · source record updated 1 July 2026.
21 England locations · 20 explicitly recorded as recruiting.
NCT05725174 · Observational
Volatile Non-Invasive Biomarkers of Epileptic Seizures
Epilepsy · Non-Epileptic Seizure
Study overall: Recruiting · source record updated 6 December 2024.
2 England locations · 2 explicitly recorded as recruiting.
NCT05745714 · Interventional
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
Acute Lymphoblastic Leukemia, in Relapse · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory
Study overall: Recruiting · source record updated 16 September 2025.
4 England locations · 0 explicitly recorded as recruiting.
NCT05745961 · Observational
Quantifying 18kDa TSPO Expression in the Lung in Pulmonary Artery Hypertension (PAH)
Pulmonary Arterial Hypertension · Healthy
Study overall: Recruiting · source record updated 15 October 2024.
1 England locations · 1 explicitly recorded as recruiting.
NCT05751044 · Interventional
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
Acute Lymphoblastic Leukemia · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent · Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory · Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory
Study overall: Recruiting · source record updated 16 September 2025.
4 England locations · 0 explicitly recorded as recruiting.
NCT05753930 · Interventional
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
Kidney Transplantation in Highly Sensitized Patients
Study overall: Recruiting · source record updated 18 August 2026.
1 England locations · 1 explicitly recorded as recruiting.
NCT05755386 · Interventional
Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN
IC-MPGN
Study overall: Recruiting · source record updated 13 July 2026.
4 England locations · 4 explicitly recorded as recruiting.
NCT05768178 · Interventional
DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.
Haematological Malignancy · Melanoma · Thyroid Cancer, Papillary · Ovarian Neoplasms · Colorectal Neoplasms · Laryngeal Neoplasms · Carcinoma, Non-Small-Cell Lung · Glioma · Multiple Myeloma · Erdheim-Chester Disease · Thyroid Carcinoma, Anaplastic · Solid Tumour
Study overall: Recruiting · source record updated 24 November 2025.
12 England locations · 12 explicitly recorded as recruiting.
NCT05770037 · Interventional
DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers
Haematological Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Anaplastic Large Cell Lymphoma · Lymphoma · Renal Cell Carcinoma · Neuroblastoma · Solid Tumour
Study overall: Recruiting · source record updated 24 November 2025.
21 England locations · 19 explicitly recorded as recruiting.
NCT05770102 · Interventional
DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition
Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Colorectal Neoplasms · Endometrial Neoplasms · Melanoma · Solid Tumours
Study overall: Recruiting · source record updated 24 November 2025.
21 England locations · 19 explicitly recorded as recruiting.
NCT05770544 · Interventional
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
Haematological Malignancy · Malignancy · Malignant Neoplasm · Lymphoproliferative Disorders · Neoplasms by Histologic Type · Neoplasms by Site · Cancer · Brain Neoplasms · Melanoma · Glioma · Solid Tumour
Study overall: Recruiting · source record updated 24 November 2025.
21 England locations · 19 explicitly recorded as recruiting.
NCT05776069 · Interventional
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Von Willebrand Diseases
Study overall: Recruiting · source record updated 26 August 2025.
5 England locations · 5 explicitly recorded as recruiting.
NCT05786716 · Interventional
DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations
Haematological Malignancy · Colorectal Neoplasms · Urinary Bladder Neoplasm · Gallbladder Neoplasms · Salivary Gland Neoplasm · Lung Neoplasm · Pancreatic Neoplasm · Ovarian Neoplasms · Prostatic Neoplasm · Skin Neoplasm · Solid Tumour
Study overall: Recruiting · source record updated 2 December 2025.
21 England locations · 19 explicitly recorded as recruiting.
NCT05786924 · Interventional
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Non-small Cell Lung Cancer · Histiocytic Neoplasm · Histiocytosis · BRAF Gene Mutation · BRAF V600E · BRAF V600 Mutation · BRAF Mutation-Related Tumors · BRAF · Metastatic Lung Non-Small Cell Carcinoma · Metastatic Lung Cancer · Recurrent Lung Cancer · Recurrent Lung Non-Small Cell Carcinoma · NSCLC · Solid Tumor · Solid Carcinoma · KRAS G12D · KRAS G12V · KRAS Mutation-Related Tumors · NRAS Gene Mutation · Thyroid Cancer · Thyroid Carcinoma · Colorectal Cancer · Colorectal Carcinoma · Recurrent Histiocytic and Dendritic Cell Neoplasm · Brain Metastases · Recurrent NSCLC · KRAS G13C · Acquired Resistance to KRAS G12C Inhibitor · KRAS G12A · KRAS G12F · KRAS G12R · KRAS G13D
Study overall: Recruiting · source record updated 17 June 2026.
3 England locations · 3 explicitly recorded as recruiting.
NCT05788536 · Interventional
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants, Adolescents and Adults With Hearing Loss Due to Otoferlin Mutations
Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)
Study overall: Recruiting · source record updated 5 August 2026.
2 England locations · 2 explicitly recorded as recruiting.
NCT05789758 · Observational
A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Before or During Pregnancy And About The Health of Their Babies
Muscular Atrophy, Spinal
Study overall: Recruiting · source record updated 9 March 2026.
10 England locations · 10 explicitly recorded as recruiting.
NCT05791864 · Interventional
A First-in-Human, Open-Label, Dose-Escalation Study to Evaluate the Safety and Tolerability of Gene Therapy With TTX-381 for the Ocular Manifestations Associated With Neuronal Ceroid Lipofuscinosis Type 2 (CLN2) Disease
Neuronal Ceroid Lipofuscinosis Type 2
Study overall: Recruiting · source record updated 18 December 2025.
1 England locations · 1 explicitly recorded as recruiting.
NCT05808543 · Interventional
BEARS Training Package to Maximise Hearing Abilities in Older Children and Teenagers With Bilateral Cochlear Implants
Hearing Loss, Sensorineural · Hearing Loss · Deafness · Hearing Impaired Children and Adolescents
Study overall: Recruiting · source record updated 1 April 2026.
12 England locations · 11 explicitly recorded as recruiting.
NCT05821959 · Interventional
Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss
Sensorineural Hearing Loss, Bilateral
Study overall: Recruiting · source record updated 4 March 2026.
1 England locations · 1 explicitly recorded as recruiting.
More ways to explore research
This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.