RESEARCH IN ENGLAND

Explore clinical trials with England locations

Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.

Condition, study or locationRecorded care areaStatus at an England locationClear filters

43 matching studies · ordered by study identifier.

The area filter uses exact source postcodes. Locations without a matched postcode remain in the England-wide results.

NCT06380751 · Interventional

Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

Advanced Breast Cancer

Study overall: Recruiting · source record updated 2 September 2026.

7 England locations · 6 explicitly recorded as recruiting.

NCT06492616 · Interventional

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

Breast Cancer

Study overall: Recruiting · source record updated 17 August 2026.

14 England locations · 14 explicitly recorded as recruiting.

NCT06525220 · Interventional

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Head and Neck Squamous Cell Carcinoma

Study overall: Recruiting · source record updated 2 June 2026.

10 England locations · 10 explicitly recorded as recruiting.

NCT06567340 · Interventional

StratCare Trial 2: Evaluating the Clinical and Cost-effectiveness of AI-driven Stratified Care for Depression

Depression

Study overall: Recruiting · source record updated 28 July 2026.

10 England locations · 10 explicitly recorded as recruiting.

NCT06598163 · Interventional

Five Lives MED to Improve Cognitive Function in Mild Cognitive Impairment

Mild Cognitive Impairment

Study overall: Recruiting · source record updated 29 April 2025.

6 England locations · 3 explicitly recorded as recruiting.

NCT06667700 · Interventional

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

Coronavirus Disease (COVID-19)

Study overall: Recruiting · source record updated 9 September 2026.

9 England locations · 9 explicitly recorded as recruiting.

NCT06712316 · Interventional

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

Non-small Cell Lung Cancer

Study overall: Recruiting · source record updated 4 September 2026.

15 England locations · 15 explicitly recorded as recruiting.

NCT06758401 · Interventional

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

Non-Small Cell Lung Cancer · Carcinoma, Non-Small-Cell Lung · Carcinoma, Non-Small-Cell Lung (NSCLC)

Study overall: Recruiting · source record updated 22 July 2026.

8 England locations · 4 explicitly recorded as recruiting.

NCT06841354 · Interventional

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Triple Negative Breast Neoplasms

Study overall: Recruiting · source record updated 3 September 2026.

7 England locations · 7 explicitly recorded as recruiting.

NCT06920342 · Observational

Attitudes to Gynae Oncology Care Location - GRACEFUL

Gynecologic Cancers

Study overall: Recruiting · source record updated 9 April 2025.

1 England locations · 1 explicitly recorded as recruiting.

NCT06989112 · Interventional

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Endometrial Cancer

Study overall: Recruiting · source record updated 3 September 2026.

7 England locations · 7 explicitly recorded as recruiting.

NCT07000357 · Interventional

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

Cardiovascular Disease

Study overall: Recruiting · source record updated 24 August 2026.

31 England locations · 31 explicitly recorded as recruiting.

NCT07037433 · Interventional

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Atherosclerotic Cardiovascular Disease · Overweight · Obesity

Study overall: Recruiting · source record updated 3 September 2026.

24 England locations · 22 explicitly recorded as recruiting.

NCT07062965 · Interventional

A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

Breast Cancer

Study overall: Recruiting · source record updated 6 May 2026.

1 England locations · 0 explicitly recorded as recruiting.

NCT07085767 · Interventional

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Breast Cancer · Locally Advanced Breast Cancer · Metastatic Breast Cancer · ER Positive Breast Cancer · HER2 Negative Breast Carcinoma

Study overall: Recruiting · source record updated 17 August 2026.

5 England locations · 5 explicitly recorded as recruiting.

NCT07091721 · Interventional

Using Mentalization Based Therapy to Support Children and Adolescents Referred to Specialist Mental Health Services in the NHS for Aggressive and/or Violent Behaviour

Conduct Disorder · Mentalization Based Therapy · Violent Behavior · Aggressive Behaviour · Adolescent Behavior · Children Behavior

Study overall: Recruiting · source record updated 8 May 2026.

8 England locations · 5 explicitly recorded as recruiting.

NCT07214779 · Interventional

Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

Ovarian Cancer

Study overall: Recruiting · source record updated 6 August 2026.

12 England locations · 8 explicitly recorded as recruiting.

NCT07351058 · Interventional

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

Obesity or Overweight · Type 2 Diabetes Mellitus

Study overall: Recruiting · source record updated 14 August 2026.

7 England locations · 7 explicitly recorded as recruiting.

NCT07359846 · Interventional

A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)

Severe Asthma

Study overall: Recruiting · source record updated 8 September 2026.

13 England locations · 13 explicitly recorded as recruiting.

NCT07413939 · Interventional

RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive

HER2-positive Breast Cancer

Study overall: Recruiting · source record updated 3 September 2026.

7 England locations · 7 explicitly recorded as recruiting.

More ways to explore research

This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.

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Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).

Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.

How we selected and connected these records

Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.