RESEARCH IN ENGLAND

Explore clinical trials with England locations

Search 2,970 registered studies with identifiable England locations in our dated ClinicalTrials.gov snapshot. Explore the study and local recruitment details before contacting the research team.

Condition, study or locationRecorded care areaStatus at an England locationClear filters

139 matching studies · ordered by study identifier.

The area filter uses exact source postcodes. Locations without a matched postcode remain in the England-wide results.

NCT05131022 · Interventional

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

Chronic Lymphocytic Leukemia (CLL) · Small Lymphocytic Lymphoma (SLL) · Diffuse Large B Cell Lymphoma (DLBCL) · Follicular Lymphoma (FL) · Mantle Cell Lymphoma (MCL) · Marginal Zone Lymphoma (MZL) · Waldenstrom Macroglobulinemia (WM) · Primary Central Nervous System Lymphoma (PCNSL) · Secondary Central Nervous System Lymphoma (SCNSL)

Study overall: Recruiting · source record updated 2 July 2026.

9 England locations · 9 explicitly recorded as recruiting.

NCT05208567 · Observational

London Valvular Heart Disease and Reduced Ejection Fraction Detection in a Multi-ethnic Community Using Cardiac Ultrasound

Heart Valve Diseases · Left Ventricular Dysfunction

Study overall: Recruiting · source record updated 23 February 2026.

1 England locations · 1 explicitly recorded as recruiting.

NCT05254743 · Interventional

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Chronic Lymphocytic Leukemia · Leukemia, Lymphocytic · Leukemia, B-cell · Small Lymphocytic Lymphoma

Study overall: Recruiting · source record updated 17 August 2026.

3 England locations · 1 explicitly recorded as recruiting.

NCT05369130 · Observational

Investigate and Predict Aortic & Thoracic Surgery Persistenet Postsurgical Pain

Persistent Postsurgical Pain

Study overall: Recruiting · source record updated 16 March 2026.

1 England locations · 1 explicitly recorded as recruiting.

NCT05413850 · Interventional

Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection

Prostate Cancer · Metastatic Castration-resistant Prostate Cancer · mCRPC · Urogenital Neoplasms · Prostatic Neoplasms · Prostatic Diseases

Study overall: Recruiting · source record updated 14 May 2026.

6 England locations · 6 explicitly recorded as recruiting.

NCT05489211 · Interventional

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

Endometrial Cancer · Gastric Cancer · Metastatic Castration-resistant Prostate Cancer · Ovarian Cancer · Colorectal Cancer · Urothelial Cancer · Biliary Tract Cancer

Study overall: Recruiting · source record updated 13 August 2026.

5 England locations · 5 explicitly recorded as recruiting.

NCT05562830 · Interventional

A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)

Urothelial Carcinoma

Study overall: Recruiting · source record updated 27 May 2026.

2 England locations · 2 explicitly recorded as recruiting.

NCT05568069 · Interventional

RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure

Heart Failure

Study overall: Recruiting · source record updated 16 June 2026.

43 England locations · 40 explicitly recorded as recruiting.

NCT05629702 · Interventional

ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

Glioblastoma · Brain Tumor · Cannabis · Brain Tumor, Recurrent

Study overall: Recruiting · source record updated 5 May 2026.

16 England locations · 14 explicitly recorded as recruiting.

NCT05633303 · Interventional

Personalised Ablation Strategies in AF

Atrium; Fibrillation

Study overall: Recruiting · source record updated 8 May 2026.

1 England locations · 1 explicitly recorded as recruiting.

NCT05646381 · Interventional

A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

Aortic Stenosis

Study overall: Recruiting · source record updated 23 June 2026.

9 England locations · 9 explicitly recorded as recruiting.

NCT05655078 · Interventional

Hemithoracic Irradiation With Proton Therapy in Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma

Study overall: Recruiting · source record updated 30 March 2026.

23 England locations · 22 explicitly recorded as recruiting.

NCT05696522 · Interventional

Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia

Radiotherapy; Complications · Ventricular Tachycardia · Structural Heart Abnormality · Heart Failure

Study overall: Recruiting · source record updated 19 June 2025.

1 England locations · 1 explicitly recorded as recruiting.

NCT05711849 · Interventional

Assessing the Safety and Effectiveness of Intracoronary Stem Cells in Patients With Refractory Angina

Refractory Angina Pectoris · Refractory Angina

Study overall: Recruiting · source record updated 7 January 2026.

1 England locations · 1 explicitly recorded as recruiting.

NCT05730036 · Interventional

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

Relapsed Refractory Multiple Myeloma (RRMM)

Study overall: Recruiting · source record updated 6 March 2026.

7 England locations · 0 explicitly recorded as recruiting.

NCT05789082 · Interventional

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Non-Small Cell Lung Cancer

Study overall: Recruiting · source record updated 8 September 2026.

1 England locations · 1 explicitly recorded as recruiting.

NCT05899608 · Interventional

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

Non-Small Cell Lung Cancer

Study overall: Recruiting · source record updated 24 August 2026.

3 England locations · 0 explicitly recorded as recruiting.

NCT06096246 · Interventional

Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)

Persistent Atrial Fibrillation · Cardiac Arrhythmia · Catheter Ablation

Study overall: Recruiting · source record updated 3 September 2025.

1 England locations · 1 explicitly recorded as recruiting.

NCT06103864 · Interventional

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

Breast Cancer

Study overall: Recruiting · source record updated 20 August 2026.

9 England locations · 5 explicitly recorded as recruiting.

NCT06129864 · Interventional

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

Locally Advanced Head and Neck Squamous Cell Carcinoma

Study overall: Recruiting · source record updated 3 September 2026.

11 England locations · 9 explicitly recorded as recruiting.

More ways to explore research

This is a selected international registry feed, not every study taking place in England. NIHR also lists participation opportunities, including studies that may not appear in this selection.

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Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).

Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.

How we selected and connected these records

Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.