NCT07075016 · EVOLVE 1
Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy
Registered research study with 16 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Acute Myeloid Leukemia
- Lead sponsor
- Stichting Hemato-Oncologie voor Volwassenen Nederland
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase3
- Study record last updated
- 19 August 2025
- Study team last verified status
- 2025-08
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| UK-Birmingham-QE Birmingham | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Blackpool-BLACKPOOLVICTORIA Blackpool | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Bristol-BRISTOLCENTRE Bristol | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Leeds-STJAMESUH Leeds | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Leicester-LEICESTERRI Leicester | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-London-KCH London | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-London-ROYALMARSDEN London | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-London-UNICOLLEGEHOSP London | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Manchester-CHRISTIE Manchester | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Manchester-ROYALINFIRMARY Manchester | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Newcastle on Tyne-FREEMAN Newcastle upon Tyne | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Nottingham-NOTTINGHAMCH Nottingham | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Oxford-CHURCHILL Oxford | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Portsmouth-QUEENALEXANDRA Portsmouth | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Southampton-SOUTHAMPTONGH Southampton | Not yet recruiting | England location Source location point within ONS England boundary |
| UK-Wolverhampton-NEWCROSSH Wolverhampton | Not yet recruiting | England location Source location point within ONS England boundary |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.