NCT06890884
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Registered research study with 12 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Lymphoma, Large B-Cell, Diffuse
- Lead sponsor
- Merck Sharp & Dohme LLC
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase2
- Study record last updated
- 3 September 2026
- Study team last verified status
- 2026-09
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Bristol Haematology and Oncology Centre ( Site 0908) Bristol · BS2 8ED | Recruiting | Care in Bristol England postcode |
| Stoke Mandeville Hospital ( Site 0917) Aylesbury · HP21 8AL | Recruiting | Care in Buckinghamshire England postcode |
| Royal Devon & Exeter Hospital ( Site 0910) Exeter · EX2 5DW | Recruiting | Care in Exeter England postcode |
| University Hospitals Plymouth NHS Trust ( Site 0905) Plymouth · PL68DH | Recruiting | Care in Plymouth England postcode |
| The James Cook University Hospital ( Site 0909) Middlesbrough · TS4 3BW | Recruiting | Care in Middlesbrough England postcode |
| Lincoln County Hospital ( Site 0906) Lincoln · LN2 5QY | Recruiting | Care in Lincoln England postcode |
| Guy s & St Thomas NHS Foundation Trust ( Site 0904) London · SE1 9RT | Recruiting | Care in Southwark England postcode |
| Hammersmith Hospital ( Site 0915) London · W12 0 HS | Recruiting | Care in Hammersmith and Fulham England postcode |
| Churchill Hospital ( Site 0903) Oxford · OX3 7LJ | Recruiting | Care in Oxford England postcode |
| Queen Elizabeth Hospital Birmingham ( Site 0912) Birmingham · B15 2TH | Recruiting | Care in Birmingham England postcode |
| Clatterbridge Cancer Centre - Liverpool ( Site 0911) Liverpool · L7 8YA | Recruiting | Care in Liverpool England postcode |
| Christie Hospital NHS Trust ( Site 0901) Manchester · M20 4BX | Recruiting | Care in Manchester England postcode |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.