NCT06790693 · INAVO123
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
Registered research study with 8 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Breast Cancer
- Lead sponsor
- Hoffmann-La Roche
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase3
- Study record last updated
- 3 September 2026
- Study team last verified status
- 2026-09
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Blackpool Victoria Hospital Blackpool · FY3 8NR | Recruiting | Care in Blackpool England postcode |
| Colchester General Hospital Colchester, Essex · CO4 5JL | Recruiting | Care in Colchester England postcode |
| Princess Alexandra Hospital Harlow · CM20 1QX | Recruiting | Care in Harlow England postcode |
| St Bartholomew's Hospital London · EC1M 6BQ | Recruiting | Care in Islington England postcode |
| Royal Free Hospital London · NW3 2QG | Recruiting | Care in Camden England postcode |
| Mount Vernon & Watford Hospital Trust Northwood · HA6 2RN | Recruiting | Care in Hillingdon England postcode |
| Churchill Hospital - Oxford Cancer & Haematology Centre Oxford · OX3 7LE | Recruiting | Care in Oxford England postcode |
| Weston Park Hospital Sheffield · S10 2SJ | Recruiting | Care in Sheffield England postcode |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.