NCT06479135 · POIESIS
Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib
Registered research study with 12 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Myelofibrosis; Post-PV MF; Post-ET Myelofibrosis; Primary Myelofibrosis; MF
- Lead sponsor
- Kartos Therapeutics, Inc.
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase3
- Study record last updated
- 25 September 2025
- Study team last verified status
- 2024-10
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Birmingham Heartlands Hospital Birmingham · B9 5SS | Recruiting | Care in Birmingham England postcode |
| Lincoln County Hospital Boston · Lincoln County Hospital | Recruiting | England location Source location point within ONS England boundary |
| Pilgrim Hospital Boston · PE21 9QS | Recruiting | Care in Boston England postcode |
| Addenbrooke's Hospital Cambridge · CB2 0QQ | Recruiting | Care in Cambridge England postcode |
| Gloucestershire Royal Hospital Gloucester · GL1 3NN | Recruiting | Care in Gloucester England postcode |
| Harrogate District Hospital Harrogate · HG2 7SX | Recruiting | Care in North Yorkshire England postcode |
| Leicester Royal Infirmary Leicester · LE1 5WW | Recruiting | Care in Leicester England postcode |
| The Clatterbridge Cancer Center NHS Foundation Trust Liverpool · L7 8YA | Recruiting | Care in Liverpool England postcode |
| University College Hospital London · NW1 2PG | Recruiting | Care in Camden England postcode |
| Guy's Hospital London · SE1 9RT | Recruiting | Care in Southwark England postcode |
| Genesis Care, Oxford Oxford · OX4 6LB | Recruiting | Care in Oxford England postcode |
| Genesis Care, Windsor Windsor · SL4 3HD | Recruiting | Care in Windsor and Maidenhead England postcode |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.