NCT06136650
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Registered research study with 12 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Metastatic Castration-resistant Prostate Cancer (mCRPC); Prostatic Neoplasms
- Lead sponsor
- Merck Sharp & Dohme LLC
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase3
- Study record last updated
- 24 August 2026
- Study team last verified status
- 2026-08
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Addenbrooke's Hospital ( Site 1426) Cambridge · CB2 2QQ | Recruiting | England location Source location point within ONS England boundary |
| Royal Derby Hospital ( Site 1431) Derby · DE22 3NE | Recruiting | Care in Derby England postcode |
| Torbay Hospital ( Site 1429) Torquay · TQ2 7AA | Recruiting | Care in Torbay England postcode |
| Mount Vernon Cancer Centre ( Site 1440) Northwood · HA6 2RN | Recruiting | Care in Hillingdon England postcode |
| The Royal Cornwall Hospital ( Site 1430) Truro · TR1 3LJ | Recruiting | Care in Cornwall England postcode |
| University College London Hospital ( Site 1437) London · NW1 2PG | Recruiting | Care in Camden England postcode |
| Guy's & St Thomas' NHS Foundation Trust-Oncology & Haematology Clinical Trials ( Site 1435) London · SE1 9RT | Recruiting | Care in Southwark England postcode |
| St. George's Hospital-Oncology ( Site 1441) London · SW17 0QT | Completed | Care in Wandsworth England postcode |
| Charing Cross Hospital ( Site 1434) London · W6 8RF | Recruiting | Care in Hammersmith and Fulham England postcode |
| GenesisCare - Oxford ( Site 1442) Oxford · OX4 6LB | Recruiting | Care in Oxford England postcode |
| GenesisCare - Windsor ( Site 1443) Windsor · SL4 3HD | Recruiting | Care in Windsor and Maidenhead England postcode |
| The Christie NHS Foundation Trust ( Site 1436) Manchester · m20 4bx | Recruiting | Care in Manchester England postcode |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.