NCT05646862 · INAVO121
A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy
Registered research study with 9 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Breast Cancer
- Lead sponsor
- Hoffmann-La Roche
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase3
- Study record last updated
- 1 September 2026
- Study team last verified status
- 2026-08
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Basingstoke and North Hampshire Hospital Basingstoke · RG24 9NA | Withdrawn | Care in Basingstoke and Deane England postcode |
| Blackpool Victoria Hospital Blackpool · FY3 8NR | Active not recruiting | Care in Blackpool England postcode |
| Princess Alexandra Hospital Harlow · CM20 1QX | Active not recruiting | Care in Harlow England postcode |
| St Bartholomew's Hospital London · EC1M 6BQ | Completed | Care in Islington England postcode |
| Maidstone & Tonbridge Wells Hospital Maidstone · ME16 9QQ | Completed | Care in Maidstone England postcode |
| Mount Vernon & Watford Hospital Trust Northwood · HA6 2RN | Active not recruiting | Care in Hillingdon England postcode |
| Churchill Hospital Oxford · OX3 7LE | Active not recruiting | Care in Oxford England postcode |
| Royal Preston Hosptial Preston · PR2 9HT | Withdrawn | Care in Preston England postcode |
| Royal Hampshire County Hospital Winchester · SO22 5DG | Withdrawn | Care in Winchester England postcode |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.