NCT05312879 · AMPLITUDE
Phase 2/3 Adaptive Study of VX-147 in Adult and Pediatric Participants With APOL1-Mediated Proteinuric Kidney Disease
Registered research study with 17 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Proteinuric Kidney Disease
- Lead sponsor
- Vertex Pharmaceuticals Incorporated
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 10 Years to 65 Years
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase2, Phase3
- Study record last updated
- 9 September 2026
- Study team last verified status
- 2026-09
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Mid and South Essex Hospitals NHS Trust Basildon | Recruiting | England location Source location point within ONS England boundary |
| FutureMeds Birmingham Birmingham | Completed | England location Source location point within ONS England boundary |
| Queen Elizabeth Hospital Birmingham Birmingham | Recruiting | England location Source location point within ONS England boundary |
| Synexus Clinical Research - Midlands (DRS) Birmingham | Completed | England location Source location point within ONS England boundary |
| Epsom and St Helier University Hospitals NHS Trust Carshalton | Completed | England location Source location point within ONS England boundary |
| Leicester General Hospital Leicester | Recruiting | England location Source location point within ONS England boundary |
| Great Ormond Street Hospital for Children London | Completed | England location Source location point within ONS England boundary |
| Guy's Hospital - Endocrinology London | Recruiting | England location Source location point within ONS England boundary |
| King's College Hospital - Pulmonology London | Recruiting | England location Source location point within ONS England boundary |
| Royal Free Hospital - Nephrology London | Recruiting | England location Source location point within ONS England boundary |
| St George's Hospital London - Nephrology London | Recruiting | England location Source location point within ONS England boundary |
| St Pancras Clinical Research London | Recruiting | England location Source location point within ONS England boundary |
| The Royal London Hospital - Nephrology London | Recruiting | England location Source location point within ONS England boundary |
| Manchester Royal Infirmary - Endocrinology Manchester | Recruiting | England location Source location point within ONS England boundary |
| Synexus Clinical Research - NW Consortium Manchester (DRS) Manchester | Recruiting | England location Source location point within ONS England boundary |
| Wythenshawe Hospital - Medicines Evaluation Unit Manchester | Recruiting | England location Source location point within ONS England boundary |
| Nottingham University Hospitals - Children's Clinical Research Facility - Pulmonology Nottingham | Recruiting | England location Source location point within ONS England boundary |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.