NCT05085028 · REFINE-Lung
A Randomised Open-label Phase III Trial of REduced Frequency Pembrolizumab immuNothErapy for First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer (NSCLC)
Registered research study with 31 identifiable England locations. See source dates, location-specific recruitment and the original study record.
Study facts
- Conditions recorded
- Lung Cancer, Nonsmall Cell
- Lead sponsor
- Imperial College London
- Study type
- Interventional
- Overall status
- Recruiting · this can differ by location
- Age range in the record
- 18 Years to Not specified
- Sex eligibility field
- All
- Healthy volunteers accepted
- No, according to the record
- Phase
- Phase3
- Study record last updated
- 7 March 2024
- Study team last verified status
- 2024-03
These fields are a starting point. Eligibility can include diagnosis, treatment history and other criteria shown only in the complete source record. A registry entry does not establish treatment effectiveness.
England study locations
A location is reproduced as named in the study record. A source map point can represent a town; it is not used here as a hospital entrance or to identify a care provider.
| Location in the source | Local recruitment status | Geographic connection |
|---|---|---|
| Royal Bournemouth Hospital Bournemouth | Recruiting | England location Source location point within ONS England boundary |
| Royal Sussex County Hospital Brighton | Recruiting | England location Source location point within ONS England boundary |
| Bristol Haematology and Oncology Centre Bristol | Recruiting | England location Source location point within ONS England boundary |
| Queen's Hospital Burton-on-Trent | Recruiting | England location Source location point within ONS England boundary |
| Cambridge University Hospitals NHS Foundation Trust Cambridge | Not yet recruiting | England location Source location point within ONS England boundary |
| East Kent Hospitals University NHS Foundation Trust Canterbury | Recruiting | England location Source location point within ONS England boundary |
| Colchester Hospital Colchester | Recruiting | England location Source location point within ONS England boundary |
| Royal Derby Hospital Derby | Recruiting | England location Source location point within ONS England boundary |
| Royal Devon and Exeter Hospital Exeter | Recruiting | England location Source location point within ONS England boundary |
| Royal Surrey NHS Foundation Trust Guildford | Not yet recruiting | England location Source location point within ONS England boundary |
| Calderdale & Huddersfield NHS Foundation Trust Huddersfield | Recruiting | England location Source location point within ONS England boundary |
| Ipswich Hospital Ipswich | Recruiting | England location Source location point within ONS England boundary |
| Kettering General Hospital Kettering | Recruiting | England location Source location point within ONS England boundary |
| Leeds Teaching Hospitals NHS Trust Leeds | Recruiting | England location Source location point within ONS England boundary |
| Leicester Royal Infirmary Leicester | Recruiting | England location Source location point within ONS England boundary |
| The Clatterbridge Cancer Centre NHS Foundation Trust Liverpool | Recruiting | England location Source location point within ONS England boundary |
| Guys Hospital London | Recruiting | England location Source location point within ONS England boundary |
| Imperial College Healthcare NHS Trust London | Recruiting | England location Source location point within ONS England boundary |
| North Middlesex University Hospital NHS Trust London | Recruiting | England location Source location point within ONS England boundary |
| St Bartholomew's Hospital London | Not yet recruiting | England location Source location point within ONS England boundary |
| The Christie NHS Foundation Trust Manchester · M20 4BX | Recruiting | Care in Manchester England postcode |
| Northampton General Hospital NHS Trust Northampton | Recruiting | England location Source location point within ONS England boundary |
| Nottingham University Hospitals NHS Trust Nottingham | Recruiting | England location Source location point within ONS England boundary |
| Peterborough City Hospital Peterborough | Recruiting | England location Source location point within ONS England boundary |
| Poole Hospital Poole | Recruiting | England location Source location point within ONS England boundary |
| Queen's Hospital, Barking Havering and Redbridge University Hospitals NHS Trust Romford | Recruiting | England location Source location point within ONS England boundary |
| Sheffield Teaching Hospitals NHS Foundation Trust Sheffield | Recruiting | England location Source location point within ONS England boundary |
| The Royal Marsden NHS Foundation Trust Sutton · SM2 5PT | Recruiting | Care in Sutton England postcode |
| Royal Cornwall Hospital Truro | Recruiting | England location Source location point within ONS England boundary |
| Worthing Hospital Worthing | Recruiting | England location Source location point within ONS England boundary |
| Yeovil Hospital Yeovil | Recruiting | England location Source location point within ONS England boundary |
Questions for the research team
- Is this exact location currently enrolling participants, and do my circumstances meet the full criteria?
- What visits, tests, possible risks and follow-up would participation involve?
- Are travel costs or accessibility arrangements available?
- How would participation affect my usual care, and what happens if I withdraw?
Source: ClinicalTrials.gov, a United States Government database. Contains OS data © Crown copyright and database right 2026. Contains National Statistics data © Crown copyright and database right 2024; ONS country boundaries (December 2024).
Source processed: 2026-09-10 09:00:04 UTC. Retrieved: 10 September 2026. ClinicalTrials.gov terms.
How we selected and connected these records
Selected registered studies with an overall status of Recruiting or Not yet recruiting and at least one England location established by postcode, recorded nation, or source coordinates within the ONS December 2024 boundary. Retained structured fields; omitted descriptions, eligibility text, contacts and non-England locations. Deduplicated identical locations. Linked local care areas only by exact postcode geography. Location points are used for nation filtering, not directions or facility matching.